{"uid":"cap_668G737qo6vVbFoCSeTGD","slug":"isth-overt-dic-score-taylor-2001-68edf732","name":"ISTH Overt DIC Score (Taylor 2001)","description":"Taylor 2001 ISTH SSC overt DIC (four lab items; max 8). Platelets >=100=0, 50-<100=1, <50=2. fibrin_related_marker none/moderate/strong = 0/2/3 (caller-assigned; magent does not grade D-dimer). PT sec above ULN <3=0, >=3 and <6=1, >=6=2. Fibrinogen >=1.0 g/L=0, <1.0=1 (XOR g/L or mg/dL÷100). Band <5 not compatible with overt DIC; >=5 compatible. Not a diagnosis. Not the non-overt serial score.","url":"https://api.magentlab.com/api/calc/isth_dic","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["platelets_10e9_l","fibrin_related_marker","pt_prolongation_sec"],"properties":{"fibrinogen_g_l":{"type":"number","description":"Fibrinogen in g/L (0.1-10). Provide this or fibrinogen_mg_dl, not both. >=1.0 scores 0; <1.0 scores 1. 1.0 scores 0 (Taylor 2001)."},"fibrinogen_mg_dl":{"type":"number","description":"Fibrinogen in mg/dL (10-1000). Converted as g/L = mg/dL / 100. Provide this or fibrinogen_g_l, not both."},"platelets_10e9_l":{"type":"number","description":"Platelet count ×10^9/L (1-2000). >=100 scores 0; 50 to <100 scores 1; <50 scores 2. 100 scores 0; 50 scores 1; 49 scores 2 (Taylor 2001)."},"pt_prolongation_sec":{"type":"number","description":"Prothrombin time prolongation in seconds above the laboratory ULN (0-30). <3 scores 0; >=3 and <6 scores 1; >=6 scores 2. 3.0 and 5.9 score 1; 6.0 scores 2; 2.9 scores 0 (Taylor 2001 table gaps filled at 3 and 6)."},"fibrin_related_marker":{"enum":["none","moderate","strong"],"type":"string","description":"Caller-assigned ISTH fibrin-related marker (Taylor 2001). none scores 0; moderate scores 2; strong scores 3. magent does not grade D-dimer assays."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"path":"/api/calc/isth_dic","count":2,"items":[{"score":0,"formula":"isth_dic","citation":{"id":"taylor-2001","doi":"10.1055/s-0037-1616068","pmid":"11816725","title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","source":"Thromb Haemost. 2001;86(5):1327-1330","authors":"Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M"},"max_score":8,"components":[{"value":180,"factor":"platelets","points":0,"present":false},{"value":"none","factor":"fibrin_related_marker","points":0,"present":false},{"value":1,"factor":"pt_prolongation","points":0,"present":false},{"value":2.5,"factor":"fibrinogen","points":0,"present":false}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","isth_dic_band":"<5","fibrinogen_g_l":2.5,"platelets_10e9_l":180,"formula_expression":"ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5","pt_prolongation_sec":1,"fibrin_related_marker":"none"},{"score":0,"formula":"isth_dic","citation":{"id":"taylor-2001","doi":"10.1055/s-0037-1616068","pmid":"11816725","title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","source":"Thromb Haemost. 2001;86(5):1327-1330","authors":"Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M"},"max_score":8,"components":[{"value":180,"factor":"platelets","points":0,"present":false},{"value":"none","factor":"fibrin_related_marker","points":0,"present":false},{"value":1,"factor":"pt_prolongation","points":0,"present":false},{"value":2.5,"factor":"fibrinogen","points":0,"present":false}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","isth_dic_band":"<5","fibrinogen_g_l":2.5,"platelets_10e9_l":180,"formula_expression":"ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5","pt_prolongation_sec":1,"fibrin_related_marker":"none"}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_whN1P49xN-9ai-bDuqNKz","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the ISTH Scientific and Standardisation Committee overt disseminated intravascular coagulation (DIC) score from four laboratory values, returning a total score and compatibility verdict.","exampleAgentPrompt":"Run the ISTH overt DIC score for a patient with platelets of 62 ×10^9/L, PT prolongation of 4.5 seconds above ULN, fibrinogen 0.8 g/L, and a strong fibrin-related marker result.","exampleUseCases":[{"title":"ICU sepsis DIC screen","prompt":"My ICU patient with sepsis has platelets of 45, PT prolonged 7 seconds above normal, fibrinogen 0.7 g/L, and D-dimer is markedly elevated so I'd call the fibrin-related marker strong — what's the ISTH overt DIC score?"},{"title":"Post-surgical coagulopathy evaluation","prompt":"Can you calculate the Taylor 2001 DIC score for a post-op patient? Platelets are 110, PT is only 2 seconds above the lab's upper limit, fibrinogen is 1.2 g/L, and fibrin marker is moderate."},{"title":"Obstetric hemorrhage DIC check","prompt":"I have an obstetric patient with suspected consumptive coagulopathy — platelets 55, PT prolonged 3.5 seconds above ULN, fibrinogen 90 mg/dL, and fibrin marker is moderate. What does the ISTH overt DIC score come back as?"}],"resultDescription":"Returns the total ISTH overt DIC score (0–8), individual sub-scores for each of the four laboratory components, and a binary interpretation: score ≥5 is compatible with overt DIC, score <5 is not compatible. Does not issue a clinical diagnosis.","failureModes":["Missing required parameters (platelets, fibrin_related_marker, or pt_prolongation_sec) returns a validation error","Providing both fibrinogen_g_l and fibrinogen_mg_dl simultaneously returns an error (XOR fields)","Out-of-range values (e.g. platelets >2000 or PT prolongation >30) may be rejected","Invalid fibrin_related_marker enum value (must be none, moderate, or strong) returns an error","Network or payment failure results in no score returned"],"whenToPreferThis":"Use this endpoint when you need a standardized, reproducible ISTH overt DIC score per the Taylor 2001 algorithm for adult patients, particularly in ICU, hematology, or obstetric workflows. Prefer this over manual calculation to eliminate arithmetic errors and ensure correct boundary handling (e.g. exactly 50 platelets scores 1, not 0). Do not use for the non-overt serial DIC score or for pediatric-specific DIC scoring systems.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T00:52:06.055Z","isFirstParty":false}