{"uid":"cap_5xpEQFwImOAlqlfrs1sdK","slug":"clinicalintelpulse-global-trials-geographic-distribution-c25da11a","name":"ClinicalIntelPulse Global Trials Geographic Distribution","description":"Global clinical trial landscape for any disease — geographic distribution by country across WHO ICTRP registries (US, EU, China, India, Japan, Brazil, Africa and more), regulatory pathways, access gaps and unmet need by region. For CRO, global-pharma and advocacy agents.","url":"https://clinicalintelpulse.theaslangroupllc.com/api/clinical/global-trials","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"queryParams":{"type":"object","properties":{"lang":{"type":"string"},"region":{"type":"string"},"condition":{"type":"string"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"errors":{"type":"object","description":"Documented error responses, keyed by HTTP status code","additionalProperties":{"type":"object","required":["description"],"properties":{"example":{"type":"object"},"description":{"type":"string"}}}},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"query_summary":{"region":"global","condition":"Malaria"},"phase3_highlights":[{"drug":"R21/Matrix-M","notes":"WHO prequalification received 2023. First malaria vaccine with >75% efficacy in high-transmission settings.","sponsor":"Serum Institute / Oxford","countries":["Burkina Faso","Kenya","Mali","Tanzania"]}],"regulatory_landscape":{"ema":"Article 58 mechanism for non-EU disease burden assessments. R21 assessed via UK MHRA.","fda":"Limited footprint — malaria not a US priority market; few NDA filings","nmpa_china":"Artemisinin derivatives approved; combination therapies standardized under WHO guidelines","who_prequalification":"Primary pathway for SSA deployment. RTS,S and R21 both WHO-prequalified."},"unmet_needs_by_region":{"latin_america":"Vivax malaria (neglected vs. falciparum)","southeast_asia":"Artemisinin resistance (Pfkrelch mutations) — urgent — treatment of resistant falciparum","sub_saharan_africa":"Pediatric dosing, pregnancy, severe malaria, transmission blocking"},"opportunity_assessment":"R21 scale-up is the near-term priority. Resistance crisis in SE Asia creates urgent Phase 3 need for alternative regimens.","global_trial_distribution":{"most_active_countries":["Kenya (45 trials)","Uganda (38)","Burkina Faso (31)","Mali (28)","Tanzania (24)","United States (22)","Thailand (19)"],"clinicaltrials_gov_count":312,"geographic_concentration":"Sub-Saharan Africa dominates — 68% of all active malaria trials","estimated_non_us_registries":"200+ additional trials in WHO ICTRP member registries"},"global_registries_coverage":{"ctri_india":"18 trials — India significant manufacturer (Serum Institute)","chictr_china":"Limited malaria — primarily domestic infectious disease","anzctr_australia":"5 trials — malaria research centers in Melbourne (Burnet Institute)","clinical_trials_eu":"12 EU-registered trials"},"development_finance_context":"GAVI, Global Fund, UNITAID, PMI, USAID funding dominant. Wellcome Trust largest private funder."}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.15","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.15/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.15","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.15","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_wHUiOIIOta43xbyWliikx","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.15","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns the global clinical trial landscape for a disease, including geographic distribution across WHO ICTRP registries, regulatory pathways, access gaps, and unmet need by region.","exampleAgentPrompt":"Show me the global clinical trial landscape for non-small cell lung cancer — I need the country-by-country distribution across WHO ICTRP registries, which regulatory pathways are active, and where the biggest access gaps or unmet need are, especially in Africa and Southeast Asia.","exampleUseCases":null,"resultDescription":"A structured breakdown of active clinical trials for the specified disease across global WHO ICTRP registries (US, EU, China, India, Japan, Brazil, Africa, and more), including trial counts by country, active regulatory pathways per region, identification of access gaps, and unmet need signals by geography. Useful for CRO site selection, market access strategy, and patient advocacy planning.","failureModes":["Unknown or misspelled disease name returns empty results or error","Very rare diseases may have sparse data with limited geographic coverage","Registry data lag may mean recently registered trials are not yet reflected","Ambiguous disease terms (e.g. 'cancer') may require more specific indication input","Rate limiting or payment failure returns 402 or 429 error"],"whenToPreferThis":"Use this endpoint when you need a bird's-eye geographic view of where clinical trials for a specific disease are being conducted globally, including regulatory pathway context and regional unmet need. Prefer this over the trial deep-dive endpoint (NCT ID lookup) when you don't have a specific trial in mind but need landscape intelligence for CRO site selection, market access analysis, global pharma strategy, or patient advocacy gap mapping.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-13T18:38:05.570Z","isFirstParty":false}