{"uid":"cap_5elfJQy7mxf3NMMdxyVP4","slug":"magent-ivt-contraindications-checker-powers-2018-table-6-class-iii-harm-17b28b31","name":"magent IVT Contraindications Checker (Powers 2018 Table 6 Class III: Harm)","description":"Powers 2018 Table 6 Class III Harm IVT. contraindicated iff any of 15 caller flags: CT ICH; recent ischemic stroke, severe head trauma, or intracranial/spinal surgery; posttraumatic infarction; history of ICH; SAH presentation; GI malignancy or bleed 21d; coagulopathy; LMWH 24h; DOAC not cleared; GP IIb/IIIa; infective endocarditis; aortic arch dissection; intra-axial neoplasm. Not Class I eligibility, time window, or a dose. magent does not read CT or assay labs. Not a treatment order.","url":"https://api.magentlab.com/api/calc/ivt_contraindications","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["ct_ich","ischemic_stroke_within_3_mo","severe_head_trauma_within_3_mo","posttraumatic_infarction_in_hospital","intracranial_spinal_surgery_within_3_mo","history_ich","sah_presentation","gi_malignancy_or_gi_bleed_21d","coagulopathy","lmwh_treatment_dose_within_24h","doac_not_cleared","gp2b3a_concurrent","infective_endocarditis","aortic_arch_dissection","intra_axial_neoplasm"],"properties":{"ct_ich":{"type":"boolean","description":"CT reveals acute intracranial hemorrhage as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read CT."},"history_ich":{"type":"boolean","description":"History of intracranial hemorrhage as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read prior imaging."},"coagulopathy":{"type":"boolean","description":"Caller-assigned coagulopathy as in Table 6 (platelets <100000/mm3 or INR >1.7 or aPTT >40 s or PT >15 s). One flag. true or false. magent does not assay labs."},"doac_not_cleared":{"type":"boolean","description":"Taking a direct thrombin or factor Xa inhibitor AND labs not documented normal AND last dose not >48 h with normal renal function, as assigned by the caller from that Table 6 row. true or false. magent does not assay labs."},"sah_presentation":{"type":"boolean","description":"Presentation most consistent with subarachnoid hemorrhage as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient."},"gp2b3a_concurrent":{"type":"boolean","description":"Concurrent GP IIb/IIIa inhibitor as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read a medication list."},"intra_axial_neoplasm":{"type":"boolean","description":"Intra-axial intracranial neoplasm as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read imaging."},"aortic_arch_dissection":{"type":"boolean","description":"Known or suspected aortic arch dissection as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient."},"infective_endocarditis":{"type":"boolean","description":"Symptoms consistent with infective endocarditis as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient."},"ischemic_stroke_within_3_mo":{"type":"boolean","description":"Prior ischemic stroke within 3 months as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not date prior strokes."},"gi_malignancy_or_gi_bleed_21d":{"type":"boolean","description":"Structural GI malignancy or GI bleed within 21 days as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient."},"lmwh_treatment_dose_within_24h":{"type":"boolean","description":"Treatment-dose LMWH within the previous 24 h as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read a medication list."},"severe_head_trauma_within_3_mo":{"type":"boolean","description":"Recent severe head trauma within 3 months as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient."},"posttraumatic_infarction_in_hospital":{"type":"boolean","description":"Posttraumatic infarction in the acute in-hospital phase as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient."},"intracranial_spinal_surgery_within_3_mo":{"type":"boolean","description":"Intracranial or spinal surgery within 3 months as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read an operative note."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_6F9rP-NkSAjlhHg6-w-Td","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Evaluates 15 caller-assigned boolean flags to determine whether IV alteplase (IVT) is contraindicated per Powers 2018 AHA/ASA Table 6 Class III: Harm criteria","exampleAgentPrompt":"My stroke patient has a history of ICH and was on LMWH within the last 24 hours — can you check whether IVT is contraindicated using the Powers 2018 Table 6 Class III Harm criteria? All other contraindication flags are false.","exampleUseCases":[{"title":"ED tPA safety screen before dosing","prompt":"Before we consider alteplase for this acute stroke patient, can you run the Powers 2018 Table 6 contraindication check? CT shows no ICH, no recent ischemic stroke, no head trauma, no prior ICH, no SAH presentation, no GI bleed or malignancy, patient has coagulopathy with INR 2.1, no LMWH, no DOAC, no GP IIb/IIIa, no endocarditis, no aortic dissection, and no intra-axial neoplasm — and no recent intracranial surgery."},{"title":"DOAC clearance contraindication flag","prompt":"This stroke patient took rivaroxaban this morning and we haven't confirmed renal clearance or documented normal labs — is IVT contraindicated under the 2018 AHA guidelines? All other 14 contraindication flags are false."},{"title":"Aortic dissection and endocarditis dual flag check","prompt":"We suspect aortic arch dissection and the patient also has known infective endocarditis. Can you confirm both of those are Class III Harm contraindications to IV alteplase per Powers 2018 Table 6, with all other flags set to false?"}],"resultDescription":"Returns a structured result indicating whether IV alteplase is contraindicated (true/false) and which of the 15 Powers 2018 Table 6 Class III Harm flags were active. Does not compute dosing, assess Class I eligibility, read CT images, or interpret lab values — all flags are caller-assigned.","failureModes":["Missing any of the 15 required boolean query parameters returns a validation error","Passing non-boolean values for flags causes schema rejection","Misassignment of flags by the caller (e.g. not reading CT correctly) leads to clinically incorrect output — the API trusts caller input entirely","Network timeout or service unavailability returns a 5xx error","Payment failure (x402) blocks the request if USDC balance is insufficient"],"whenToPreferThis":"Use this endpoint when you need a fast, rule-based check of the 15 Powers 2018 AHA/ASA Table 6 Class III Harm contraindications to IV alteplase in acute ischemic stroke, and all flags have already been clinically assessed by the caller. Do not use it to determine Class I eligibility, compute dosing, interpret CT images, or assay lab values. Prefer this over manual checklist review when building automated stroke triage workflows or clinical decision support pipelines.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T12:41:21.453Z","isFirstParty":false}