{"uid":"cap_55UfEa8qKIw2z1JqcCIuK","slug":"sitecheck-health-travel-gwas-catalog-associations-by-gene-0e77128f","name":"SiteCheck Health & Travel – GWAS Catalog Associations by Gene","description":"EMBL-EBI GWAS Catalog genome-wide association hits for a gene symbol (REST API v2): reported trait, EFO trait, SNP and locus, p-value, odds ratio or beta, study accession and PubMed ID. Searches by mapped gene only. Up to 10 hits per call.","url":"https://api.healthtravel-api.workers.dev/api/health/gwas-catalog-associations?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET"],"type":"string"},"queryParams":{"type":"object","required":["gene"],"properties":{"max":{"type":"string","description":"How many associations, 1 to 10 (default 5)"},"gene":{"type":"string","description":"Gene symbol, letters, digits and hyphens, 2 to 20 characters"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.002","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.002/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_WIuPPSlyqeQr0cY67m0QN","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.002","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns genome-wide association study (GWAS) hits from the EMBL-EBI GWAS Catalog for a given gene symbol, including trait, SNP, p-value, odds ratio, and study metadata.","exampleAgentPrompt":"Pull up to 8 GWAS Catalog association hits for the gene APOE — I want to see the reported traits, SNPs, p-values, and PubMed IDs for each one.","exampleUseCases":[{"title":"Genetic risk factors for Type 2 Diabetes","prompt":"What GWAS hits does the GWAS Catalog have for the TCF7L2 gene? Give me up to 10 results with the trait, SNP, p-value, and study accession."},{"title":"Cardiovascular gene variant research","prompt":"Look up GWAS associations for the PCSK9 gene — I want to see the EFO trait, odds ratio, and the PubMed ID for each hit, up to 5 results."},{"title":"Alzheimer's disease genomic associations","prompt":"Fetch the top 10 GWAS Catalog entries mapped to the APOE gene, including the reported trait, SNP locus, p-value, and any linked study accessions."}],"resultDescription":"Returns up to 10 GWAS association records for the queried gene symbol. Each record includes the reported trait name, EFO ontology trait, SNP identifier and locus, p-value, odds ratio or beta coefficient, GWAS study accession number, and PubMed ID of the source publication.","failureModes":["Invalid or unrecognized gene symbol returns no results or an error","Gene symbol with no GWAS Catalog associations returns an empty result set","max parameter outside 1–10 range may be rejected or clamped","EMBL-EBI API downtime causes upstream fetch failure","Gene symbol too short (<2 chars) or too long (>20 chars) rejected by schema validation"],"whenToPreferThis":"Use this endpoint when you need structured GWAS hit data (SNPs, traits, p-values, odds ratios, study references) for a specific gene symbol from the authoritative EMBL-EBI GWAS Catalog. Prefer it over general genomics databases when you specifically need mapped-gene GWAS associations with EFO trait ontology and study provenance (PubMed/accession). Not suitable for variant-level clinical significance (use ClinVar for that) or for querying by disease/trait rather than gene.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T12:39:16.621Z","isFirstParty":false,"canonicalSlug":"sitecheck-health-travel-gwas-catalog-associations-by-gene-0e77128f"}