{"uid":"cap_4doKPuyyEAJmCPvACMBDU","slug":"osiris-osteoporosis-index-of-risk-calculator-sedrine-2002-8a75a86e","name":"OSIRIS Osteoporosis Index of Risk Calculator (Sedrine 2002)","description":"Sedrine 2002 Osteoporosis Index of Risk (OSIRIS). Index = (-0.2 × age) + (0.2 × weight_kg) + 2 if current HRT + (-2) if prior low-impact fracture. Risk low if score > +1, high if score < -3, intermediate otherwise including exact +1 and -3. Age 18-120; weight_kg or weight_lb; current_hrt and prior_low_impact_fracture true/false. Not a medical device, not FRAX, not a DXA order. Derivation was postmenopausal Western European women.","url":"https://api.magentlab.com/api/calc/osiris","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","current_hrt","prior_low_impact_fracture"],"properties":{"age":{"type":"integer","description":"Age in years (18-120). Sedrine 2002 OSIRIS uses age as a whole number of years."},"weight_kg":{"type":"number","description":"Weight in kilograms. Provide weight_kg or weight_lb."},"weight_lb":{"type":"number","description":"Weight in pounds. Converted as kg = lb * 0.45359237."},"current_hrt":{"type":"boolean","description":"Current HRT/estrogen use (Sedrine 2002). true adds +2; false adds 0. true or false."},"prior_low_impact_fracture":{"type":"boolean","description":"Prior low-impact fracture (Sedrine 2002). true adds -2; false adds 0. true or false."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_bv9L-fWSIxiW_TmhnvhxG","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the OSIRIS score and risk category for osteoporosis screening in postmenopausal women using age, weight, HRT status, and fracture history.","exampleAgentPrompt":"Calculate the OSIRIS osteoporosis risk score for a 67-year-old woman who weighs 58 kg, is currently on hormone replacement therapy, and has no prior low-impact fractures.","exampleUseCases":[{"title":"Pre-DXA osteoporosis triage","prompt":"I have a 72-year-old postmenopausal patient weighing 52 kg, not on HRT, who had a wrist fracture from a minor fall last year — can you calculate her OSIRIS score and tell me if she's high risk for osteoporosis?"},{"title":"Routine clinic screening workflow","prompt":"Run the OSIRIS osteoporosis screening score for a 58-year-old woman, 140 lbs, currently taking estrogen, and no history of low-impact fractures — what category does she fall into?"},{"title":"Assess impact of stopping HRT on risk","prompt":"My patient is 65 years old, weighs 61 kg, and just stopped hormone therapy — she has no prior fractures. What is her OSIRIS osteoporosis risk score now that she's off HRT?"}],"resultDescription":"Returns a numeric OSIRIS index value computed as (-0.2 × age) + (0.2 × weight_kg) + 2 if current HRT + (-2) if prior low-impact fracture, along with a categorical risk classification: low (score > +1), high (score < -3), or intermediate (score between -3 and +1 inclusive).","failureModes":["Missing required parameters (age, current_hrt, prior_low_impact_fracture) returns a 400 error","Age outside 18–120 range may be rejected or produce unreliable results","Neither weight_kg nor weight_lb provided results in an error","Non-boolean values for current_hrt or prior_low_impact_fracture cause validation failure","Payment failure (x402) blocks the request if USDC balance is insufficient"],"whenToPreferThis":"Use this endpoint when you need a fast, validated pre-screening score for osteoporosis risk in postmenopausal women, particularly when DXA is not yet available or to decide if DXA referral is warranted. It implements the specific Sedrine 2002 OSIRIS formula — prefer it over generic risk calculators when you need this validated index. Not appropriate as a substitute for FRAX, DXA ordering, or clinical diagnosis.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T07:12:23.567Z","isFirstParty":false}