{"uid":"cap_4MTvlH-zSBrU-95agSzLz","slug":"fiona-glp-1-research-query-a9a8ca08","name":"Fiona GLP-1 Research Query","description":"User Generated App","url":"https://fiona-125b95be.base44.app/functions/queryGated","method":"POST","headers":{},"bodySchema":{"type":"object","required":["question"],"properties":{"question":{"type":"string","description":"Your research question about GLP-1 drugs, clinical trials, or obesity treatments"},"max_results":{"type":"number","description":"Max results to return (default: 10)"}}},"responseSchema":{"type":"object","properties":{"topic":{"type":"string"},"answer":{"type":"string","description":"Synthesized research answer with citations"},"sources":{"type":"array","items":{"type":"object","properties":{"url":{"type":"string"},"date":{"type":"string"},"title":{"type":"string"},"source":{"type":"string"}}}},"question":{"type":"string"},"timestamp":{"type":"string"},"items_searched":{"type":"number"}}},"example":{"request":{"question":"What are the clinical trial outcomes for GLP-1 receptor agonists in obesity treatment?","max_results":10},"response":{"topic":"GLP-1","answer":"**Quick Answer**\nGrowing clinical evidence that GLP-1 receptor agonists reduce cravings for alcohol, nicotine, and opioids — opening new indications beyond obesity.\n\n**Key Findings**\n• **GLP-1 drugs and addiction: surprising effects on alcohol and smoking** (PubMed, 2026)\n  Growing clinical evidence that GLP-1 receptor agonists reduce cravings for alcohol, nicotine, and opioids — opening new indications beyond obesity....\n  🔗 https://pubmed.ncbi.nlm.nih.gov/\n\n• **GLP-1 and Alzheimer's: promising early data on neurological benefits** (PubMed, 2026)\n  Early clinical data suggests GLP-1 receptor agonists may reduce Alzheimer's risk and slow cognitive decline, with major trials now underway....\n  🔗 https://pubmed.ncbi.nlm.nih.gov/\n\n• **GLP-1 drugs and fertility: what the data shows** (PubMed, 2026)\n  New data on GLP-1 receptor agonists' effects on PCOS, fertility outcomes, and pregnancy safety, showing improved ovulation in women with PCOS....\n  🔗 https://pubmed.ncbi.nlm.nih.gov/\n\n• **GLP-1 receptor agonists and kidney protection: new evidence** (PubMed, 2026)\n  Multiple large trials confirm GLP-1 receptor agonists provide significant kidney protection in patients with obesity and type 2 diabetes, independent of weight loss....\n  🔗 https://pubmed.ncbi.nlm.nih.gov/\n\n**What to Watch Next**\n• Retatrutide Phase 3 TRIUMPH trial readouts\n• Oral GLP-1 (orforglipron) FDA decision August 2026\n• GLP-1 for NASH/MASH liver disease approvals\n\n---\n*10 sources. Updated 6/12/2026.*","sources":[{"url":"https://pubmed.ncbi.nlm.nih.gov/","date":"2026","title":"GLP-1 drugs and addiction: surprising effects on alcohol and smoking","source":"PubMed"},{"url":"https://pubmed.ncbi.nlm.nih.gov/","date":"2026","title":"GLP-1 and Alzheimer's: promising early data on neurological benefits","source":"PubMed"},{"url":"https://pubmed.ncbi.nlm.nih.gov/","date":"2026","title":"GLP-1 drugs and fertility: what the data shows","source":"PubMed"},{"url":"https://pubmed.ncbi.nlm.nih.gov/","date":"2026","title":"GLP-1 receptor agonists and kidney protection: new evidence","source":"PubMed"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41785010/","date":"2026","title":"Retatrutide in type 2 diabetes mellitus and obesity: an overview.","source":"PubMed"}],"question":"What are the clinical trial outcomes for GLP-1 receptor agonists in obesity treatment?","timestamp":"2026-06-12T04:43:38.156Z","free_trial":true,"items_searched":36,"free_trial_note":"Free trial. Future queries require payment via x402.","payment_settled":false}},"exampleRequest":{"question":"What are the clinical trial outcomes for GLP-1 receptor agonists in obesity treatment?","max_results":10},"tags":["x402"],"displayCostAmount":"0.05","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.05/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.05","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.05","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_VNOnUe_nGEfCYxhoxe3Ug","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.05","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Answers research questions about GLP-1 drugs, clinical trials, and obesity treatments with synthesized citations","exampleAgentPrompt":"What does current clinical research say about the long-term cardiovascular benefits of semaglutide in obese patients — give me up to 15 sources?","exampleUseCases":[{"title":"Compile GLP-1 side effects research for patient","prompt":"I need to research what clinical trials say about common side effects of tirzepatide. Can you find me the latest evidence with citations so I can discuss this with my doctor?"},{"title":"Compare obesity treatment options with evidence","prompt":"Help me understand the research differences between GLP-1 drugs and bariatric surgery for weight loss. I want credible sources I can actually read through."},{"title":"Find recent drug approval and efficacy data","prompt":"What's the latest clinical research on liraglutide for type 2 diabetes? I need synthesized findings with proper citations for a health discussion."}],"resultDescription":"Returns a synthesized research answer with citations, including the topic, the original question, a timestamp, and an array of sources each with URL, title, publication date, and source name, plus the number of items searched.","failureModes":["Missing required 'question' field returns validation error","Overly broad or ambiguous question may return low-quality synthesis","Payment failure (x402 protocol) returns 402 Payment Required before query is processed","Rate limiting or server error may return 5xx response","No relevant results found may return empty sources array with limited answer"],"whenToPreferThis":"Use this endpoint when you need synthesized, cited research answers specifically about GLP-1 drugs, obesity treatments, or related clinical trials — not general medical or pharmaceutical questions. Ideal when a user needs a research-quality answer with traceable sources rather than a simple fact lookup.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T12:45:08.250Z","isFirstParty":false}