{"uid":"cap_2OubipdEhXz1Cel1-n6AV","slug":"polyform-drug-brief-api-d44aa149","name":"Polyform Drug Brief API","description":"Pay-per-call data endpoints for AI agents. USDC on Base via x402. No account, no API key — one micropayment per call.","url":"https://api.polyform.org/v1/health/drug-brief?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET"],"type":"string"},"queryParams":{"type":"object","properties":{}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"rxcui":"83367","generic":"atorvastatin","topAdverseReactions":[{"term":"FATIGUE","reports":14405}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.05","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.05/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.05","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.05","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_CU1yGCGb-c3V54Zuz8lGY","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.05","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns a brief drug profile for a given drug name or RxCUI, including its generic name and top adverse reactions from FDA FAERS data","exampleAgentPrompt":"Can you pull up the drug brief for atorvastatin — I need its RxCUI, generic name, and the top adverse reactions reported to the FDA?","exampleUseCases":[{"title":"Drug safety check for patient counseling","prompt":"What are the most commonly reported adverse reactions for metformin according to FDA data? I need the generic name and top side effects."},{"title":"RxCUI resolution for EHR integration","prompt":"I need the RxCUI and generic drug name for lisinopril — can you fetch that from the drug brief API?"},{"title":"Pharmacovigilance research on side effects","prompt":"Pull up the drug brief for warfarin — I want to see which adverse reactions have the most FDA reports so I can flag the highest-risk ones."}],"resultDescription":"A JSON object containing the drug's RxCUI identifier, its generic name, and an array of top adverse reactions each with the reaction term and number of FDA FAERS reports (e.g. {rxcui: '83367', generic: 'atorvastatin', topAdverseReactions: [{term: 'FATIGUE', reports: 14405}]}).","failureModes":["Drug name not recognized — returns error or empty result if the queried drug cannot be matched","Payment failure — if the x402 micropayment of $0.05 USDC is not completed, request is rejected","Invalid query parameters — malformed or missing required fields return a 400-level error","Rate or network issues — transient failures on the Base blockchain payment layer may cause timeouts"],"whenToPreferThis":"Choose this endpoint when you need a fast, no-account drug safety lookup — particularly the generic name and top FDA-reported adverse reactions — without provisioning API keys or subscriptions. Ideal for AI agents that need pay-per-use drug data on demand via USDC micropayment on Base (x402 protocol). Prefer this over full clinical databases when a concise drug brief is sufficient and cost-per-call economics matter.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-10T18:42:42.644Z","isFirstParty":false,"canonicalSlug":"polyform-drug-brief-api-d44aa149"}