{"uid":"cap_1IYAedNWXq2JKwBC5W7PV","slug":"magent-icc-2022-systemic-mastocytosis-criteria-calculator-2ca73eb3","name":"magent ICC 2022 Systemic Mastocytosis Criteria Calculator","description":"ICC 2022 systemic mastocytosis (Arber 2022). Met when major infiltrates (≥15 tryptase- and/or CD117-positive MCs in aggregates in BM or extracutaneous organ) alone, or ≥3 minors. Minors: >25% spindle or atypical immature morphology, KIT D816V or other activating KIT mutation, CD25/CD2/CD30, tryptase >20 ng/mL (not counted in SM-AMN). Not a diagnosis. Not Valent 2016 WHO SM. Not WHO 5th/Khoury. Not cutaneous mastocytosis only. magent does not read a biopsy or assay tryptase.","url":"https://api.magentlab.com/api/calc/icc_sm","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["major_infiltrates","atypical_or_spindle","kit_activating","cd2_cd25_or_cd30","tryptase_gt_20","associated_myeloid_neoplasm"],"properties":{"kit_activating":{"type":"boolean","description":"KIT D816V or other activating KIT mutation in bone marrow, blood, or an extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM minor; not codon-816-only). true or false. magent does not sequence KIT."},"tryptase_gt_20":{"type":"boolean","description":"Serum tryptase persistently >20 ng/mL as assigned by the caller (Arber 2022 ICC SM minor). Does not count when associated_myeloid_neoplasm is true (SM-AMN). true or false. magent does not assay tryptase."},"cd2_cd25_or_cd30":{"type":"boolean","description":"Mast cells express CD25, CD2, and/or CD30 in addition to mast-cell markers, as assigned by the caller (Arber 2022 ICC SM minor; ICC adds CD30). true or false. magent does not phenotype mast cells."},"major_infiltrates":{"type":"boolean","description":"Multifocal dense infiltrates of tryptase- and/or CD117-positive mast cells (≥15 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM major). true or false. magent does not read a biopsy."},"atypical_or_spindle":{"type":"boolean","description":">25% spindle-shaped or atypical immature morphology in bone marrow or extracutaneous sections, as assigned by the caller (Arber 2022 ICC SM minor). true or false. magent does not read slides."},"associated_myeloid_neoplasm":{"type":"boolean","description":"Associated myeloid neoplasm (ICC SM-AMN) as assigned by the caller. When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagnose a myeloid neoplasm."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_ltGrMzWdfGz_ogW7wGohH","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Evaluates caller-assigned ICC 2022 (Arber) criteria for systemic mastocytosis, returning whether the major criterion and/or sufficient minor criteria are met","exampleAgentPrompt":"This patient has major bone marrow mast cell infiltrates, KIT D816V mutation, and CD25 expression but serum tryptase is only 18 ng/mL — they also have an associated myeloid neoplasm. Do they meet ICC 2022 systemic mastocytosis criteria?","exampleUseCases":[{"title":"SM-AMN tryptase exclusion check","prompt":"Patient has major infiltrates in the bone marrow, KIT activating mutation, and CD25-positive mast cells, plus a concurrent myeloid neoplasm — but tryptase is 22 ng/mL. Does the tryptase minor criterion still count under ICC 2022 SM rules for SM-AMN, and do they meet criteria overall?"},{"title":"Minor criteria count with no major infiltrates","prompt":"My patient doesn't have major mast cell aggregates on biopsy, but has atypical spindle morphology, KIT D816V, and CD30 expression — tryptase is 25 ng/mL and no associated myeloid neoplasm. Do they meet ICC 2022 systemic mastocytosis criteria without the major criterion?"},{"title":"Borderline ICC SM ruling for clinical note","prompt":"I have a patient with no major infiltrates, no KIT mutation, no CD25/CD2/CD30, serum tryptase 18 ng/mL, and no associated myeloid neoplasm — but they have spindle-shaped mast cell morphology. Do they meet ICC 2022 Arber SM criteria, and how many minor criteria are satisfied?"}],"resultDescription":"Returns a structured result indicating whether the ICC 2022 (Arber) systemic mastocytosis major criterion is met, how many minor criteria are satisfied, whether overall SM criteria are fulfilled (major alone, or ≥3 minors), and whether the associated myeloid neoplasm flag suppressed the tryptase minor criterion (SM-AMN rule).","failureModes":["Missing required boolean parameters returns a validation error","Misunderstanding SM-AMN: caller may incorrectly include tryptase as a minor when associated_myeloid_neoplasm is true — the API enforces the exclusion","Endpoint does not interpret pathology, flow cytometry, or lab values — all criteria must be pre-assigned by the caller","Does not apply WHO 5th edition or Valent 2016 WHO SM criteria — wrong endpoint if those classifications are needed","Does not diagnose or output a diagnosis — result is a criteria evaluation only"],"whenToPreferThis":"Use this endpoint when you need to apply the specific ICC 2022 (Arber) systemic mastocytosis criteria, including the SM-AMN tryptase exclusion rule and CD30 as a minor criterion. Prefer this over other SM criteria tools when your workflow already has discrete boolean clinical findings (major infiltrates, morphology, KIT mutation, immunophenotype, tryptase, AMN status) pre-assigned by a clinician or upstream pipeline, and you need a reliable, auditable arithmetic evaluation. Do not use if you need WHO 5th edition (Khoury), Valent 2016, or cutaneous mastocytosis classification.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:21:01.542Z","isFirstParty":false}