{"uid":"cap_0gqR4NCPleAQf6w4Im0Bu","slug":"protein-domain-family-lookup-by-uniprot-accession-78613ed9","name":"Protein Domain & Family Lookup by UniProt Accession","description":"Look up protein domains, families and conserved sites with GO terms and sequence locations.","url":"https://win.oneshotagent.com/v1/tools/lookup/protein-domains?utm_source=zero.xyz","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"types":{"type":"array","items":{"enum":["family","domain","homologous_superfamily","repeat","conserved_site","active_site","binding_site","ptm"],"type":"string"},"description":"Keep only these entry types; omitted means all types"},"accession":{"type":"string","description":"The canonical UniProt accession identifying the protein, for example P04637; isoforms are not accepted"}}},"responseSchema":{"type":"json","example":{"entries":[{"name":"p53, central conserved site","type":"conserved_site","go_terms":[],"page_url":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR057064/","locations":[{"end":249,"start":237,"discontinuous":false}],"interpro_id":"IPR057064"}],"accession":"P04637","truncated":false,"protein_length":393}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_IQzJdBaFYThHToo_KXqUE","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Look up InterPro protein domains, families, conserved sites, binding sites, and other functional regions with GO terms and sequence locations for a given UniProt accession.","exampleAgentPrompt":"Look up all protein domains, conserved sites, and binding sites for UniProt accession P04637 — include GO terms and sequence locations for each entry.","exampleUseCases":[{"title":"TP53 tumor suppressor domain mapping","prompt":"Can you fetch all the InterPro domain and conserved site annotations for the TP53 protein — UniProt accession P04637 — including the sequence start and end positions for each?"},{"title":"Filtering for active and binding sites only","prompt":"For UniProt accession Q9Y6K9, pull only the active_site and binding_site entries from InterPro, and show me the GO terms associated with each."},{"title":"Protein family classification for drug target","prompt":"I need to know what protein families and homologous superfamilies UniProt accession P00533 (EGFR) belongs to — can you get those InterPro annotations for me?"}],"resultDescription":"Returns a JSON object with the UniProt accession, total protein length, a truncation flag, and a list of InterPro entries each containing: entry name, type (family/domain/conserved_site/etc.), InterPro ID, a link to the EBI InterPro page, a list of GO terms, and one or more sequence location ranges (start, end, discontinuous).","failureModes":["Invalid or unrecognized UniProt accession returns an error or empty entries list","Isoform accessions (e.g. P04637-2) are not accepted and will fail","Protein with no InterPro annotations returns an empty entries array","Invalid entry type enum values in the types filter cause a validation error","Network or payment (x402) failures return HTTP 402 or 5xx errors"],"whenToPreferThis":"Use this endpoint when you need structured, position-resolved InterPro functional annotations (domains, families, active sites, binding sites, PTMs, conserved sites) for a specific protein identified by its canonical UniProt accession. Prefer this over text-based literature search when you need machine-readable GO terms and precise sequence coordinates for downstream analysis, visualization, or comparison workflows.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T07:20:44.102Z","isFirstParty":false,"canonicalSlug":"protein-domain-family-lookup-by-uniprot-accession-78613ed9"}