{"uid":"cap_06piL1p17mSfIFDyFBvPC","slug":"delta-p-score-calculator-for-lems-associated-sclc-85391b6e","name":"DELTA-P Score Calculator for LEMS-Associated SCLC","description":"Titulaer 2011 DELTA-P for SCLC association in Lambert-Eaton myasthenic syndrome. One point each, at or within 3 months of LEMS onset: bulbar weakness (dysarthria/dysphagia/chewing/neck weakness); erectile dysfunction if male (always 0 if female); weight loss ≥5%; smoking at onset; age ≥50; Karnofsky <70. Max 6. Bands low 0-1, intermediate 2, high 3-6. Published SCLC percents for scores 0, 1, 3-6; none for score 2. Not a LEMS diagnosis, not SOX1, and not an SCLC screen.","url":"https://api.magentlab.com/api/calc/delta_p","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["sex","age","bulbar_weakness","weight_loss_ge_5pct","smoking_at_onset","kps_lt_70"],"properties":{"age":{"type":"integer","description":"Age at LEMS onset in years (18-120). ≥50 scores 1; 49 does not (Titulaer 2011)."},"sex":{"enum":["female","male"],"type":"string","description":"female or male. Erectile dysfunction scores only when male. Female erectile is always 0 (Titulaer 2011: Female | 0)."},"kps_lt_70":{"type":"boolean","description":"Karnofsky Performance Status 0-60 (KPS <70) at or within 3 months of LEMS onset (Titulaer 2011 P). Caller-assigned flag; magent does not compute Karnofsky. true or false. 1 point if true."},"bulbar_weakness":{"type":"boolean","description":"Dysarthria, dysphagia, chewing difficulty, or neck weakness at or within 3 months of LEMS onset (Titulaer 2011 D). true or false. Caller-assigned. 1 point if true."},"smoking_at_onset":{"type":"boolean","description":"Smoking at LEMS onset (Titulaer 2011 T). true or false. Caller-assigned. 1 point if true."},"weight_loss_ge_5pct":{"type":"boolean","description":"Weight loss ≥5% at or within 3 months of LEMS onset (Titulaer 2011 L). true or false. Caller-assigned. 1 point if true."},"erectile_dysfunction":{"type":"boolean","description":"Erectile dysfunction at or within 3 months of LEMS onset (Titulaer 2011 E). Required when sex is male (true scores 1). When female, this item is always 0, including if omitted, false, or true. true or false."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_83ayQJ8BHdmLf2PWrzX5u","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Titulaer 2011 DELTA-P score to estimate probability of small-cell lung cancer (SCLC) in patients with Lambert-Eaton myasthenic syndrome (LEMS)","exampleAgentPrompt":"Calculate the DELTA-P score for a 62-year-old male LEMS patient who smokes, has bulbar weakness and lost 7% of his body weight, does not have erectile dysfunction, and has a Karnofsky score of 80 — what is his SCLC risk band?","exampleUseCases":[{"title":"SCLC risk stratification at LEMS diagnosis","prompt":"I have a newly diagnosed LEMS patient: 58-year-old female, smoker at onset, bulbar weakness present, weight loss of 6%, Karnofsky 65. What is her DELTA-P score and which SCLC risk band does she fall into?"},{"title":"Ruling out high SCLC risk in young non-smoker","prompt":"My LEMS patient is a 43-year-old male, non-smoker, no bulbar weakness, no weight loss, no erectile dysfunction, Karnofsky 90. Can you run the DELTA-P and tell me if he's in the low-risk band?"},{"title":"Documentation support for oncology referral","prompt":"I need to document the DELTA-P score for a 71-year-old male LEMS patient who was smoking at onset, has bulbar weakness, lost 8% body weight, has erectile dysfunction, and has a Karnofsky of 50 — what is his total score and associated SCLC probability?"}],"resultDescription":"Returns the integer DELTA-P total score (0–6), the risk band classification (low 0–1, intermediate 2, high 3–6), and the published SCLC percentage associated with that score from Titulaer 2011 where available (note: no published percentage exists for score 2).","failureModes":["Missing required query parameters (sex, age, or boolean flags) returns a validation error","Age outside 18–120 range may be rejected","Sex value not matching 'male' or 'female' enum causes error","Providing erectile_dysfunction=true for a female patient is silently treated as 0 per Titulaer 2011 rules","Payment not provided or insufficient results in 402 response"],"whenToPreferThis":"Use this endpoint when a clinician or clinical decision support agent needs to quantitatively estimate SCLC risk in a known or suspected LEMS patient using the validated Titulaer 2011 DELTA-P criteria. This is not a LEMS diagnostic tool, does not replace SOX1 antibody testing, and is not a general lung cancer screen — it applies only after LEMS is established.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T18:49:33.631Z","isFirstParty":false}